NEONATAL TRANSPLANTATION CONFERS MATURATION OF PSC-DERIVED CARDIOMYOCYTES CONDUCIVE TO MODELING CARDIOMYOPATHY

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy

Summary: Pluripotent stem cells (PSCs) offer unprecedented opportunities for disease modeling and personalized medicine.However, PSC-derived cells exhibit fetal-like characteristics and remain immature in a dish.This has emerged as a major obstacle for their application for late-onset diseases.We previously showed that there is a neonatal arrest of

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Neurological images in phenylketonuria (PKU)

Phenylketonuria is erbaviva sunscreen an inborn error of metabolism that causes structural abnormalities in the white matter of the brain.In untreated patients demyelization can be observed, and there is evidence of intramyelin edema even in some treated patients.Imaging studies especially magnetic resonance imaging are useful for the study of pati

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Lipidomic Profiling Identifies a Novel Lipid Signature Associated with Ethnicity-Specific Disparity of Bladder Cancer

Bladder Cancer shamrock belt buckle (BLCA) is the ninth most frequently diagnosed cancer globally and the sixth most common cancer in the US.African Americans (AA) exhibit half the BLCA incidence compared to European Americans (EA), but they have a 70% higher risk of cancer-related death; unfortunately, this disparity in BLCA mortality remains poor

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Oculomotor deficits in aryl hydrocarbon receptor null mouse.

The Aryl hydrocarbon Receptor or AhR, a ligand-activated transcription factor, is known to mediate the toxic and carcinogenic effects of various environmental pollutants such as 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD).Recent studies in Caenorhabditis elegans and Drosophila melanogaster show that the orthologs of the AhR are expressed exclusively

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Some Design Considerations For High-power High-voltage Dc/dc Converter With Improved Power Density And Efficiency

This paper presents the findings of a R&D project connected to the development of 50 kW auxiliary power supply for the high-voltage DC-fed commuter trains.The aim was to design a new-generation power converter utilizing high-voltage apunisw2 IGBT modules, which can outpace the predecessor (6.5 kV IGBT based twolevel half-bridge DC/DC converter) in

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