Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy
Summary: Pluripotent stem cells (PSCs) offer unprecedented opportunities for disease modeling and personalized medicine.However, PSC-derived cells exhibit fetal-like characteristics and remain immature in a dish.This has emerged as a major obstacle for their application for late-onset diseases.We previously showed that there is a neonatal arrest of